Translational gene mapping of cognitive decline
نویسندگان
چکیده
منابع مشابه
Translational gene mapping of cognitive decline.
The ability to maintain cognitive function during aging is a complex process subject to genetic and environmental influences. Alzheimer's disease (AD) is the most common disorder causing cognitive decline among the elderly. Among those with AD, there is broad variation in the relationship between AD neuropathology and clinical manifestations of dementia. Differences in expression of genes invol...
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Andrea Talesa,∗, Frank Jessenb,c, Christopher Butlerd, Gordon Wilcockd, Judith Phillipse and Tony Bayerf aCollege of Human and Health Sciences, Department of Psychology, Swansea University, Swansea, Wales, UK bDepartment of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany cGerman Center for Neurodegenerative Disorders (DZNE), Germany dNuffield Department of Clinical Neurosci...
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INTRODUCTION Age-associated cognitive decline-or normal (non-pathological, normative, usual) cognitive ageing-is an important human experience which differs in extent between individuals. The determinants of the differences in age-related cognitive decline are not fully understood. Progress in the field is taking place across many areas of biomedical and psychosocial sciences. AREAS OF AGREEM...
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Stroke and cognitive impairment are common among older persons.1 It is estimated that the lifetime risk for stroke is approximately 1 in 5 for women and 1 in 6 for men,2 and almost one-third of persons with stroke, which typically may involve motor, sensory, or other deficits, may have a significant degree of cognitive impairment within several months of the event.1 Furthermore, silent strokes ...
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Across a range of psychometric tests, reaction times slow as adult age increases. These changes have been widely taken to show that cognitive-processing capacities decline across the lifespan. Contrary to this, we suggest that slower responses are not a sign of processing deficits, but instead reflect a growing search problem, which escalates as learning increases the amount of information in m...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2008
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2006.11.008